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DNA double-helix molecule
Feb 27, 2012
A new study finds that genes in different pathways influence progression to different stages of age-related macular degeneration (AMD). AMD is known to be influenced primarily by genetic factors, although environmental and behavioral factors also play important roles. Multiple studies have shown that several genes in the alternative complement...

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Calculator
Feb 26, 2012
When patients are told by their ophthalmologist that they have early signs of age-related macular degeneration (AMD), they often ask about the risk of their AMD progressing. Long-term epidemiological studies that have collected information on the prevalence, incidence, and natural history of AMD provide data to answer this question. These studies...

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Dry Macular Degeneration
Feb 26, 2012
Researchers have developed a risk score for developing geographic atrophy (GA) involving easily obtainable information among patients with bilateral large drusen. Choroidal neovascularization (CNV) and geographic atrophy (GA) are two forms of end-stage AMD. GA is responsible for about 10% of the severe vision loss attributed to the AMD, and...

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Calculator
Feb 26, 2012
Researchers have designed a new risk assessment model for development of advanced age-related macular degeneration (AMD) incorporating phenotypic, demographic, environmental, and genetic risk factors. As progress in designing better preventive measures and earlier treatment options accelerates and new gene associations are identified that add...

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Macular degeneration
Feb 25, 2012
A new study finds that the gene for complement factor H (CFH) confers more risk to the bilaterality of geographic atrophy, whereas the gene for HTRA1/LOC387715 contributes more to the bilaterality of choroidal neovascularization (CNV). Because AMD is one of the most studied common eye diseases of the past 5 years, knowledge of its genetic basis...

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Double helix DNA
Feb 24, 2012
AMD has been one of the success stories of the genome revolution and is probably one of the best characterized of the complex trait diseases in terms of genetic predisposition. Besides age, genetic background is the most significant non-modifiable risk factor for all stages of AMD, while smoking is the most significant modifiable risk factor....

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Visudyne
Feb 17, 2012
A new study finds an association between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and response to treatment with photodynamic therapy (PDT) for age-related macular degeneration (AMD) in a Japanese population. Studies...

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DNA double-helix molecule
Feb 16, 2012
A new study finds that among patients with wet AMD those with higher risk genotypes response better to Lucentis (ranibizumab) therapy than patients with lower risk genotypes. Epidemiological and association studies have shown that both genetic and environmental factors play a major role in the development of AMD. Association studies have...

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Lucentis
Feb 15, 2012
Age-related macular degeneration (AMD) has a complex etiology arising from genetic and environmental influences. This past decade have seen several genes associated with the disease. Variants in five genes have been confirmed to play a major role. It is hoped that such research will define the genetic biomarker spectrum to allow treatment...

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Vegetables are good for maintaining eye health
Feb 14, 2012
A new study finds that high dietary intake of nutrients with antioxidant properties reduces the risk of early AMD in those at high genetic risk. Therefore, clinicians should provide dietary advice to young susceptible individuals to postpone or prevent the vision-disabling consequences of AMD. The etiology of AMD is complex with both genetic...

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DNA double-helix molecule
Feb 14, 2012
Extensive epidemiologic and genetic analyses have lead to the conclusion that AMD, like many other chronic age-related diseases, results from the interplay of multiple environmental and genetic factors, which in combination account for development of the phenotype. The condition is strongly age-related, and tobacco smoking is the most consistent...

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Lutein supplement
Feb 12, 2012
A new study finds that lutein supplementation increases MPOD, and a correlation was found between the change in MPOD and the change in VA and MDLT such that patients who show a pronounced increase in MPOD also benefit in terms of visual function. Genetic and environmental risk factors for age-related macular degeneration (AMD) have been...

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