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Displaying news items tagged with VEGF (More tags »)
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DNA double-helix molecule
Feb 14, 2012
Extensive epidemiologic and genetic analyses have lead to the conclusion that AMD, like many other chronic age-related diseases, results from the interplay of multiple environmental and genetic factors, which in combination account for development of the phenotype. The condition is strongly age-related, and tobacco smoking is the most consistent...

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Intravitreal injection
Feb 26, 2011
The judicious use of anti-VEGF agents for the treatment of age-related macular degeneration (AMD) is reasonable, considering the biological and clinical responses, a speaker said at Macula 2011 meeting. Anti-VEGF injections can be associated with elevated IOP, tachyphylaxis (drug resistance) and reduced ocular perfusion, Elias Reichel, MD, said...

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Eyeglasses
Nov 22, 2010
Levels of VEGF in normal patients undergoing cataract surgery are lower among myopic eyes than hyperopic eyes, according to a new study. It is known that there is a reduced prevalence of exudative age-related macular degeneration (AMD) among persons with myopia (near-sightedness). Other studies have revealed that intraocular neovascularization...

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retinal nerve fiber layer
Aug 25, 2010
Long-term intravitreal injection of anti–vascular endothelial growth factor (VEGF) agents does not adversely affect on the thickness of the retinal nerve fiber layer (RNFL) in patients with wet age-related macular degeneration (AMD). The use of intravitreal anti-VEGF agents has become the standard of care for patients with AMD. The duration...

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VEGF molecule
Jul 24, 2010
A new study finds that VEGF-A165b is a potent antiangiogenic agent in a mouse model of age-related macular degeneration (AMD) and suggests that increasing the ratio of antiangiogenic-to-proangiogenic VEGF isoforms may be therapeutically effective in this condition. Vascular endothelial growth factor (VEGF-A) is the principal stimulator of...

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Laboratory mouse
Jun 25, 2010
A new study finds that nontarget 21nt-siRNA can suppress laser-induced choroidal neovascularization (CNV) anatomically and functionally through VEGF suppression. Blindness in age-related macular degeneration (AMD) results predominantly from invasion of the retina by CNV. Targeting vascular endothelial growth factor (VEGF)-A has been validated...

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Avastin
Jun 16, 2010
The decreased levels of blood VEGF after an intravitreal injection of Avastin (bevacizumab) indicate that Avastin enters the general circulation and may also affect the PEDF levels. There continues to be a concern regarding the long term health consequences of intravitreal Avastin therapy. VEGF plays an important role in many parts of the body...

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VEGF molecule
Jan 24, 2010
The concentration of vascular endothelial growth factor (VEGF) in the aqueous humour of eyes with myopic choroidal neovascularization (mCNV) is less than that found in normal control eyes, according to a new research report. Extreme myopia may produce degenerative changes of the retina. These degenerative changes may lead to complications such...

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Tags: myopia, VEGF

Avastin
Jan 20, 2010
Avastin (bevacizumab) decreases survival of cultured retinal pigment epithelial cells stressed by hydrogen peroxide, according to a new study. Vascular endothelial cell growth factor (VEGF) is strongly induced by oxidative stress in retinal pigment epithelial (RPE) cells, and VEGF-A is a survival factor for various cell types. VEGF-A expression...

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VEGF molecule
Dec 17, 2009
Intravitreal Lucentis (ranibizumab) injections in patients with neovascular AMD results in decreased aqueous levels of VEGF and increased levels of platelet-derived growth factor (PDGF). Methods and results In this prospective clinical trial 28 eyes of patients with neovascular AMD were compared with 28 eyes of age-matched patients with...

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