MyVisionTest News Archive

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Age-related Macular Degeneration
Oct 25, 2010
An oral retinol-binding protein inhibitor showed promising results in a phase 2 proof of concept study for geographic atrophy, a clinician reported at the joint meeting of the American Academy of Ophthalmology and Middle East Africa Council of Ophthalmology. Fenretinide (ReVision Therapeutics) slowed the progression of advanced dry age-related...

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Dry Macular Degeneration
Mar 26, 2010
Acucela Inc. and Otsuka Pharmaceutical Co. have announced that they have received Fast Track designation from the U.S. Food and Drug Administration (FDA) for ACU-4429, an investigational oral treatment for dry age-related macular degeneration (dry AMD). The FDA's Fast Track programs are designed to facilitate the development and expedite the...

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Dry macular degeneration
May 22, 2009
Acucela presented new safety, tolerability and effectiveness data on ACU-4429, an investigational therapy for dry age-related macular degeneration (AMD), at the 2009 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. Study participants tolerated ACU-4429 well in single-dose tests conducted with healthy volunteers age 55...

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Complement pathway
Mar 19, 2009
The retinal pigment epithelium (RPE) is responsible for digesting the waste products of the photoreceptors. The digestion process is very efficient, but a tiny fraction of the waste is chemically indigestible, and will accumulate within the RPE. A hallmark of aging is the accumulation of undigested waste products in the form of lipofuscin within...

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Laboratory mouse
Nov 23, 2008
An investigational drug called retinylamine slowed the progression of a condition in mice that is very similar to age-related macular degeneration (AMD) in humans. The AMD-like condition was triggered in mice by disrupting the removal of all-trans-retinal from the retina. Under normal conditions, the visual pigment 11-cis-retinylidene is...

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Diagram of a mitochondria
Sep 22, 2008
Eating plenty of antioxidant-rich food such as blueberries, artichokes and pecans may help protect against macular degeneration, the leading cause of age-related blindness in the United States and other developed countries. U.S. researchers found that antioxidants disrupt a link between two processes in the retina that, in combination,...

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Dry macular degeneration
Sep 18, 2008
Acucela and Otsuka Pharmaceutical announced that they have entered into an agreement to co-develop ACU-4429, which is currently in Phase I clinical development for the dry form of age-related macular degeneration (AMD) in the United States. ACU-4429 is small molecule non-retinoid visual cycle modulator. The compound is expected to slow the...

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Laboratory mouse
Sep 8, 2008
Dietary supplementation with vitamin A is sometimes prescribed as a treatment for retinitis pigmentosa, a group of inherited retinal degenerations that cause progressive blindness. Mutations in the ABCA4 gene are responsible for a subset of recessive retinitis pigmentosa and related diseases, recessive cone-rod dystrophy, and recessive Stargardt...

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Vegetables are good for maintaining eye health
Aug 21, 2008
A new study reveals part of the magic behind a diet rich in antioxidants. The study shows how artichokes, blueberries and pecans can hold age-related macular degeneration (AMD) at bay. Researchers discovered a link between two processes in the retina that, in combination, contribute to AMD. They found antioxidants disrupt the link and extend...

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Dry macular degeneration
Jun 6, 2008
An oral medication that targets A2E, a major component of lipofuscin - a toxin that accumulates within the retina in a variety of macular diseases, including AMD and Stargart's disease - entered Phase I trials on 5 June 2008. Acucela, a biotechnology company, announced that it has dosed the first subject in a Phase I trial for its lead...

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