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Laboratory glassware
Sep 21, 2010
VEGF antagonists, such as Avastin (bevacizumab) and Lucentis (ranibizumab), impair the barrier function of cultured retinal pigment epithelium (RPE) cells, according to a new study. In spite of the favorable results of anti-VEGF therapies in the treatment of exudative age-related macular degeneration (AMD), several adverse incidents are related...

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Pigment epithelial detachment
Jun 17, 2010
In patients with age-related macular degeneration (AMD) and pigment epithelial detachment (PED) secondary to occult choroidal neovascularization (CNV), Avastin (bevacizumab) therapy decreased PED height but this does not necessarily correlate with improvment in visual acuity (VA), according to a new study. A PED occurs when fluid enters the...

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Drusenoid pigment epithelial detachment
Mar 29, 2010
The natural history of eyes containing drusenoid pigment epithelial detachment (DPED) is characterized by a high rate of progression to both central geographic atropy (CGA) and neovascular age-related macular degeneration (NV-AMD), according to a new report from the AREDS study group. Among eyes not progressing to advanced AMD, progressive...

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Pigment epithelial detachment
Feb 21, 2010
Combined intravitreal triamcinolone acetonide (IVTA) injection with intravitreal Avastin (bevacizumab, IVB) is effective in the treatment of choroidal neovascularization (CNV) associated with large retinal pigment epithelial detachment (PED) in age-related macular degeneration (AMD), according to a new study. A PED occurs when fluid enters the...

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Polypoidal choroidal vasculopathy
Feb 15, 2010
Researchers describe choroidal vascular abnormalities outside the macula in patients with polypoidal choroidal vasculopathy (PCV). Polypoidal choroidal vasculopathy (PCV) involves branching vascular networks external to the choriocapillaris and multiple, terminal reddish orange, aneurysmal or polypoidal lesions. Indocyanine green angiography is...

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Pigment epithelial detachment
Nov 26, 2009
Lucentis (ranibizumab) is ineffective in treating avascular pigment epithelial detachment (PED) secondary to age-related macular degeneration (AMD) over a 1 year follow-up period, according to a new study. A PED occurs when fluid enters the space between the retinal pigment epithelium (RPE) and choroid (Figure). A serous PED is when aqueous...

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Age-related macular degeneration
Oct 26, 2009
Lpath, Inc. reported positive results of its single-dose Phase 1 clinical trial of iSONEP, an anti-sphingosine-1-phosphate monoclonal antibody, in neovascular age-related macular degeneration (AMD) patients. iSONEP met its primary endpoint of being well tolerated in all 15 patients at dose-levels ranging from 0.2 mg. to 1.8 mg. per...

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Pigment epithelial detachment
Oct 22, 2009
Anti-VEGF injections may be beneficial for treatment of pigment epithelium detachment secondary to neovascular age-related macular degeneration, a population that previously has not been studied in clinical trials, according to a speaker at Retina Congress 2009. In 35 patients with pigment epithelium detachment secondary to AMD, Lucentis (...

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Pigment epithelial detachment
Jul 20, 2009
Combined photodynamic therapy (PDT) and intravitreal Avastin (bevacizumab) injection is effective in the treatment of serous pigment epithelial detachment (PED) associated with age-related macular degeneration (AMD), according to a new study. A PED occurs when fluid enters the space between the retinal pigment epithelium (RPE) and choroid (...

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Retinal pigment epithelium tear
Jul 17, 2009
A new study finds that RPE tears following intravitreal Lucentis (ranibizumab) injections for classic CNV can occur in about 5% of patients, even in the absence of baseline RPE detachment. RPE tears are a serious complication of anti-VEGF drug therapy. An RPE tear occurs when a break develops in the RPE of a PED. Most studies have found that...

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