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Dry Macular Degeneration
Oct 25, 2010
Ongoing clinical trials exploring the use of complement inhibitors for treating nonexudative age-related macular degeneration offer promise for a disease state that has long been considered difficult to treat, according to a speaker at the joint meeting of the American Academy of Ophthalmology and the Middle East Africa Council of Ophthalmology....

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Double helix DNA
Oct 21, 2010
A new study finds the combination of elevated C-reactive protein (CRP) levels and the high-risk genotype of the complement factor H (CFH) gene resulted in a super-additive risk for age-related macular degeneration (AMD) progression. The complement factor H (CFH) gene, involved in the alternate complement pathway, has been consistently...

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DNA double-helix molecule
Aug 28, 2010
A genome-wide association study has identified a possible role of the hepatic lipase gene (LIPC) in advanced AMD, according to a new research report. These findings implicate a new biologic pathway in AMD and provide new avenues for prevention and treatment of AMD. The role of the alternative complement pathway in disease pathogenesis was...

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Obesity
Aug 28, 2010
High-sensitivity C-reactive protein (CRP) and polymorphisms in the CFH and ARMS2/HTRA1 genes are independently associated with risk of AMD, according to a new research study. Higher CRP level tends to confer a higher risk of age-related macular degeneration (AMD) within most genotype groups. Studies have documented the importance of genetic,...

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Macular degeneration
Aug 26, 2010
Despite the success of intravitreal anti-VEGF therapy in treating age-related macular degeneration, serious concerns abound over the potential burden of repeated injections. Although still in the early stages of development, candidate drug therapies could offer the theoretical potential of enhancing anti-VEGF efficacy and, perhaps, leading to...

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Drusenoid pigment epithelial detachment
May 9, 2010
Intravitreal injection of an anti-VEGF agent and a complement inhibitor proved safe in treating age-related macular degeneration, Dr Scott Cousins, said at the Association for Research in Vision and Ophthalmology 2010 meeting. "Drusen contain all the different complement family of molecules, not just the effectors but also the activator and...

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Double helix DNA
Mar 28, 2010
A convergence of scientific and clinical observations and new technologies paved the way for a hallmark genetic discovery that changed the course of AMD research. Four articles published early in 2005 demonstrated an association between AMD and common variants (or polymorphisms) in the complement factor H gene (CFH) on human chromosome 1q31, a...

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Double helix DNA
Oct 14, 2009
Persons with the CFH CC genotype have an increased likelihood of bilateral compared with unilateral age-related macular degeneration (AMD), according to a new study. AMD is an irreversible debilitating disease with complex genetic and environmental contributors. Recent research has focused on identifying the genetic predisposition to AMD, and...

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Laboratory mouse
Jul 28, 2009
Using a synthetic form of complement factor H (fH), called CR2-fH, researchers were able to inhibit development of choroidal neovascularization (CNV) in a mouse model of age-related macular degeneration (AMD). Studies on the pathogenesis of AMD indicate that inflammation is a fundamental component of the disease process and that the alternative...

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cardiovascular system
Jun 16, 2009
A new study finds evidence of systemic complement activation in patients with recent onset exudative age-related macular degeneration (AMD). It is belived that chronic inflammatory processes play a role in the progression of AMD. The complement system plays an important role in modulating the inflammatory response. Activation of the complement...

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