The clinical characteristics of a large series of patients with punctate inner choroidopathy (PIC) is presented in a new research report. The term punctate inner choroidopathy (PIC) was first used by Watzke et al in 1984 to describe findings in a group of 10 patients with multifocal, well-circumscribed, usually small choroidal lesions. These...

Tumor necrosis factor alpha (TNF)-α contributes to inflammation-associated angiogenesis. This study finds that TNF-α mice that lack receptor 1a suffered worse choroidal neovascularization (CNV), and mice that lack 1b receptors had reduced CNV. TNF-α is a cytokine that stimulates the expression of proangiogenic VEGF, induces...

Pericytes, the contractile cells surrounding capillaries, may use mechanical forces to initiate angiogenesis, the "sprouting" of new blood vessels, according to a new study. The study is among the first to examine mechanical signaling by pericytes as a potential driver of angiogenesis. Previously, scientists have focused on the chemical...

Intravitreal injection of ketorolac (Acular) into the eyes of laboratory rats significantly inhibited the growth of laser-induced choroidal neovascularization (CNV), according to a recently published report. A growing body of scientific evidence indicates that inflammation plays a central role in the development of choroidal neovascularization (...

Myopic choroidal neovascularisation (mCNV) may develop secondary to choroidal vascular insufficiency, according to a new study. High myopia is associated with excessive and progressive elongation of the globe, resulting in a variety of fundus changes that lead to visual impairment, including lacquer cracks in the Bruch membrane, choroidal...

The vision of patients with persistent or reactivated choroidal neovascularization (CNV) that had been previously treated with photodynamic therapy (PDT) improve less than treatment-naive patients. Baseline assessments including best-corrected visual acuity, fluorescein angiography (FFA), and optical coherent tomography (OCT) were performed....

Avastin (bevacizumab) is effective in the treatment of choroidal neovascularization (CNV) and cystoid macular edema (CME) secondary to inflammatory eye disease, according to a new research study. Choroidal neovascularization (CNV) and cystoid macular edema (CME) are well-recognized complications of inflammatory eye disease and important causes...

In a study on laboratory rats, orally administrated doxycycline, an inexpensive and widely used broad-spectrum antibiotic, was found to reach the choroid and effectively hampered the progression of experimental choroidal neovascularization. Doxycycline is a member of the tetracycline antibiotics group that is clinically useful because of its...

A new study examining the relationship between the choriocapillaris (CC) and retinal pigment epithelial changes in age-related macular degeneration (AMD) finds that the primary insult in geographic atrophy (GA) appears to be at the level of the retinal pigment epithelium (RPE), where retinal pigment epithelial atrophy preceeds secondary...

The creation of a full-thickness autologous patch (FTAP) for choroidal neovascularization through a 180° peripheral retinotomy is feasible and safe. This retrospective study evaluated the feasibility of transplanting a full-thickness patch of choroid, choriocapillaries, Bruch’s membrane and RPE (RPE-choroid FTAP) from the peripheral to the...