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Macular degeneration
Aug 26, 2010
Despite the success of intravitreal anti-VEGF therapy in treating age-related macular degeneration, serious concerns abound over the potential burden of repeated injections. Although still in the early stages of development, candidate drug therapies could offer the theoretical potential of enhancing anti-VEGF efficacy and, perhaps, leading to...

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Monkey
Oct 15, 2009
Intravitreal JSM6427, a potent and selective inhibitor of integrin α5β1, provided dose-dependent inhibition of choroidal neovascularization (CNV) in monkey and rabbit experimental models; suggesting that JSM6427 may provide a new approach for the treatment of ocular neovascular diseases such as age-related macular degeneration (AMD) in...

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Macular degeneration
May 22, 2009
Volociximab, an alpha-5 beta-1 integrin antagonist, combined with Lucentis (ranibizumab) treatments for wet age-related macular degeneration is showing a favorable safety profile in early phase 1 studies, according to a poster presentation at the 2009 Association for Research in Vision and Ophthalmology meeting. Baruch D. Kupperman, MD, and...

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Eye Drops
Apr 17, 2009
SARcode Corporation announced today the results of its Phase 1 trial of the safety, tolerability, and pharmacokinetics of SAR 1118 Ophthalmic Solution in healthy volunteers. SAR 1118 was well-tolerated and demonstrated a favorable safety profile when administered by topical ocular instillation. SAR 1118 is a potent novel small molecule...

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Macular degeneration
Feb 10, 2009
Many physicians are awaiting the results of a trial comparing two leading anti-VEGF agents in the treatment of neovascular age-related macular degeneration (wet AMD). But because study results will not be known for several years, they continue to practice with varying therapies, regimens and doses, trying to find an ideal treatment for their...

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Age-related Macular Degeneration
Jan 19, 2009
Retinal pigmented epithelium (RPE) transplantation has been assessed as a potential technique to preserve the visual function in persons with age-related macular degeneration (AMD). However, RPE survival following transplantation is limited, in part, because of lack of attachment of the transplanted cells to Bruch's membrane. Integrins are a...

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Laboratory mouse
Dec 5, 2008
A new study finds that an integrin αvβ3 antagonist known as BS-1417 inhibits choroidal neovascularization (CNV) in mice. Integrins are a class of cell surface receptors that play a key role in the regulation of numerous key processes, including cell proliferation, migration, and differentiation. Integrins bind with various components in the...

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Diabetes
Nov 22, 2008
This article investigates the role of integrins in proliferative diabetic retinopathy, and concludes that they represent a potential target for the development of new drug therapies for the disease. Integrins have also been identified as playing a role in the pathogenesis of choroidal neovascularization. Proliferative diabetic retinopathy...

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Age-related Macular Degeneration
Nov 21, 2008
Ophthotech has recently announced the initiation of two phase 1 clinical trials for new drugs designed to treat age-related macular degeration (AMD). One drug is an anti-C5 complement factor aptamer known as ARC1905. The second drug is a monoclonal antibody targeting α5β1 integrin called Volociximab, and it's antiangiogenic properties are being...

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