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Dry Macular Degeneration
Feb 27, 2011
A deficiency of an enzyme that degrades RNA, known as DICER1, may cause dry age-related macular degeneration, according to a new study. Age-related macular degeneration (AMD), which is as prevalent as cancer in industrialized countries, is a leading cause of blindness. In contrast to neovascular AMD, the more common atrophic form of AMD is...

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Laboratory mouse
Nov 22, 2010
N-acetyl-cysteine (NAC) inhibited the development of laser-induced choroidal neovascularization (CNV) in mice, according to a new study. Chemically, N-acetyl-cysteine (NAC) is similar to the amino acid cysteine. Amino acids are the building blocks of proteins. NAC is a potent antioxidant and has many uses in medicine. NAC acts as a cysteine...

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Liposome
Aug 27, 2010
Researchers demonstrate that non-viral gene therapy can delay the onset of some forms of retinal degeneration and preserve vision, according to a new study. The researchers developed nanoparticles to deliver therapeutic genes to the retina and found that treated mice temporarily retained more eyesight than controls. "Our work shows that...

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Laboratory mouse
Jul 27, 2010
Tumor necrosis factor alpha (TNF)-α contributes to inflammation-associated angiogenesis. This study finds that TNF-α mice that lack receptor 1a suffered worse choroidal neovascularization (CNV), and mice that lack 1b receptors had reduced CNV. TNF-α is a cytokine that stimulates the expression of proangiogenic VEGF, induces...

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VEGF molecule
Jul 24, 2010
A new study finds that VEGF-A165b is a potent antiangiogenic agent in a mouse model of age-related macular degeneration (AMD) and suggests that increasing the ratio of antiangiogenic-to-proangiogenic VEGF isoforms may be therapeutically effective in this condition. Vascular endothelial growth factor (VEGF-A) is the principal stimulator of...

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Laboratory mouse
Jun 27, 2010
A new study finds that inhibition of CXCR4 may be useful in preventing neovascularization but does not appear to have an effect on already established angiogenesis, whereas a multiple receptor tyrosine kinase inhibitor (SU14813) reduced the size of previously formed lesions. Endothelial precursor cells (EPCs) derived from hematopoietic stem...

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Laboratory mouse
Jun 25, 2010
A new study finds that nontarget 21nt-siRNA can suppress laser-induced choroidal neovascularization (CNV) anatomically and functionally through VEGF suppression. Blindness in age-related macular degeneration (AMD) results predominantly from invasion of the retina by CNV. Targeting vascular endothelial growth factor (VEGF)-A has been validated...

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Laboratory glassware
May 17, 2010
Quark Pharmaceuticals announced that researchers from Pfizer, Inc. presented data on in vivo activity of PF-04523655 at the Association for Research in Vision and Ophthalmology (ARVO) 2010 annual meeting. The study demonstrated reduction of RTP801 mRNA levels in rat retina following intravitreal administration of PF-04523655 in a laser model of...

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Laboratory mouse
May 16, 2010
Intravitreal injection of ketorolac (Acular) into the eyes of laboratory rats significantly inhibited the growth of laser-induced choroidal neovascularization (CNV), according to a recently published report. A growing body of scientific evidence indicates that inflammation plays a central role in the development of choroidal neovascularization (...

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Laboratory mouse
Mar 26, 2010
Large changes in blood pressure do not result in changes in chodoidal blood flow (ChBF) in rats, according to a new study. It has been suggested that changes in choroidal blood flow is a key factor in the development of age-related macular degeneration (AMD). Artiosclerosis and blood pressure are suspected to play a role in creating choroidal...

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