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Laboratory mouse
Jul 27, 2010
Tumor necrosis factor alpha (TNF)-α contributes to inflammation-associated angiogenesis. This study finds that TNF-α mice that lack receptor 1a suffered worse choroidal neovascularization (CNV), and mice that lack 1b receptors had reduced CNV. TNF-α is a cytokine that stimulates the expression of proangiogenic VEGF, induces...

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Remicade
May 19, 2009
A series of three patients with neovascular age-related macular degeneration (AMD) successfully treated off-label with Remicade (infliximab), an anti-tumor necrosis factor (TNF) monoclonal antibody has been published. Remicade has been approved by the U.S. Food and Drug Administration for the treatment of psoriasis, Crohn's disease,...

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Monkey
Apr 17, 2009
ESBATech has announced preclinical results, which demonstrate efficacy of topical ESBA105, an anti-Tumor Necrosis Factor (TNF) single-chain antibody fragment, in a model for choroidal neovascularization (CNV). In wet age-related macular degeneration (wet AMD), CNV causes the formation of new blood vessels growing behind the retina, which can...

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