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Eylea
Jan 16, 2012
Genentech and Regeneron Pharmaceuticals have agreed to a partial settlement with regard to ophthalmic sales of aflibercept injections in the United States, according to a press release. Under the plan, Regeneron will receive a non-exclusive license to certain patents for VEGF receptor proteins as well as to other technology patents, the release...

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CATT trial logo
Jan 15, 2012
The long-awaited primary outcome of the Comparison of Age-related Macular Degeneration Treatments Trial (CATT) study was that patients receiving either monthly Avastin (bevacizumab) or monthly Lucentis (ranibizumab) had equivalent visual acuity at 1 year. For the majority of clinicians who already preferentially used Avastin for age-related...

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CATT trial logo
Jan 15, 2012
The much anticipated CATT study has now been published. The National Eye Institute is to be applauded for having sponsored this landmark trial and for setting a new standard of transparency by submitting most of the raw data on the Internet. Millions of people who cannot afford Lucentis (ranibizumab) now have the benefit of a high level of...

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CATT trial logo
Jan 14, 2012
For 5 years, patients and clinicians have wrestled with the choice between two drugs for the treatment of neovascular age-related macular degeneration (AMD). Vascular endothelial growth factor (VEGF), the cytokine primarily responsible for blood-vessel growth, is inhibited when anti-VEGF drugs are injected repeatedly into the eye, and blindness is...

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Avastin
Jan 14, 2012
The authors report a cluster of 14 consecutive cases of sterile endophthalmitis occurred after intravitreal injection of Avastin (bevacizumab) obtained from a single batch that occured in Japan circa 2009. Intravitreous Avastin (IVB) can cause complications, including traumatic cataract, retinal detachment, and endophthalmitis, with the...

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Intravitreal injection
Jan 14, 2012
Elevated intraocular pressure (IOP) after an intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents for age-related macular degeneration (AMD) is not uncommon, but this study failed to identify any significant risk factors for its occurrence. Studies investigating transient increases in intraocular pressure (IOP)...

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Intraocular pressure
Jan 14, 2012
Neovascular age-related macular degeneration (AMD) patients undergoing unilateral intravitreal Lucentis (ranibizumab) and/or Avastin (bevacizumab) injections are more likely to suffer intraocular pressure (IOP) elevation of at least 5 mmHg of 2 or more visits if they recieve a greater number of injections, according to a new study. Intravitreal...

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Avastin
Jan 14, 2012
Intraocular injections of anti–vascular endothelial growth factor (VEGF) agents have yielded dramatic improvements in the management of a wide variety of neovascular ocular diseases including age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal vein occlusion, and retinopathy of prematurity. These agents have thus become...

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CATT trial logo
Jan 8, 2012
Avastin and Lucentis had equivalent effects on visual acuity at 1 year, accirding to the much anticipated Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) research group. Clinical trials have established the efficacy of Lucentis (ranibizumab) for the treatment of neovascular age-related macular degeneration (AMD). In...

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Avastin
Jan 7, 2012
Health Canada is warning the public and doctors about cases of blindness in the U.S. that have been linked to off-label use of the drug Avastin. Three clusters of cases of serious complications including blindness have been reported in the United States after the drug was used to treat macular degeneration, the department said in a statement in...

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