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Displaying news items tagged with wet AMD (More tags »)
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VEGF molecule
Nov 19, 2009
Lucentis (ranibizumab) therapy for neovascular age-related macular degeneration (AMD) is associated with reduced levels of aqueous VEGF and pigment epithelium-derived factor (PEDF) regardless of combined therapy with photodynamic therapy (PDT). The reduction levels of VEGF and PEDF are correlated with anatomic improvements in the macula. A...

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Lucentis
Nov 17, 2009
Same-day verteporfin photodynamic therapy (PDT) and intravitreal Lucentis (ranibizumab) is safe and effective in the treatment of patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD), according to a new study. In this open-label, prospective study patients received verteporfin PDT at...

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Dry Macular Degeneration
Oct 26, 2009
Although patients with dry age-related macular degeneration may have clinically superior vision than patients with wet AMD, the nonexudative form can nonetheless negatively affect the patient's functional vision, according to a speaker at the American Academy of Ophthalmology meeting. In a review of 467 patients with both forms of the disease,...

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VEGF-Trap
Oct 26, 2009
Data from the extension study of VEGF-Trap suggest clinically significant improvements in vision with low dosing burden and a favorable safety profile, according to a speaker at the American Academy of Ophthalmology meeting. In the CLEAR-IT 2 extension study, 117 patients were followed with as-needed therapy with VEGF-Trap (Aflibercept,...

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Central retinal vein occlusion
Oct 26, 2009
Genentech, Inc. announced results from two Phase III studies of Lucentis (ranibizumab) in macular edema due to retinal vein occlusion (RVO), which showed patients given Lucentis had significant improvement in best-corrected visual acuity (BCVA) at six months compared to patients receiving sham injections. Results from both trials were presented at...

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Age-related macular degeneration
Oct 26, 2009
Lpath, Inc. reported positive results of its single-dose Phase 1 clinical trial of iSONEP, an anti-sphingosine-1-phosphate monoclonal antibody, in neovascular age-related macular degeneration (AMD) patients. iSONEP met its primary endpoint of being well tolerated in all 15 patients at dose-levels ranging from 0.2 mg. to 1.8 mg. per...

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Macular degeneration
Oct 26, 2009
Investigators have shown, at 6 months in a small group of patients, that there is no difference in efficacy between Avastin (bevacizumab) and Lucentis (ranibizumab) for the treatment of age-related macular degeneration (AMD). The study is the first to report early outcomes of a prospective, double-masked, randomized, controlled trial comparing...

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Asian family
Oct 26, 2009
A single sub-Tenon injection of triamcinolone acetonide (STTA) combined with with photodynamic therapy (PDT) for the treatment of age-related macular degeneration (AMD) reduces the need for retreatment in Japanese patients without polypoidal choroidal vasculopathy (PCV) but not in patients with PCV. The medical records of 111 eyes of 111...

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DNA double-helix molecule
Oct 24, 2009
Genetic variants, especially located on chromosomes 1 and 10, appear to correlate with phenotypic expressions of age-related macular degeneration. The most well known of these genetic risk factors, Ivana K. Kim, MD, said at Retina Subspecialty Day preceding the American Academy of Ophthalmology meeting, is complement factor H (CFH), which has...

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Intravitreal injection
Oct 24, 2009
Despite the adoption of non-monthly anti-VEGF dosing schedules by some retinal experts for treatment of exudative age-related macular degeneration, clinical trial evidence to date has not definitively proven that as-needed therapy is either superior or inferior to monthly dosing, according to a speaker at the American Academy of Ophthalmology....

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