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Racial groups
Jan 16, 2012
Age-related Macular Degeneration (AMD) has long been thought to be more frequent in non-Hispanic whites than in blacks in the United States. This was based on observations reported in clinical case series. The use of new AMD classification schemes and severity scales in large population-based studies has confirmed that non-Hispanic whites have...

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Racial diversity
Jan 16, 2012
The 4-year incidence and progression of age-related macular degeneration (AMD) in Latinos are lower than in non-Hispanic whites, according to a report from the Latino Eye Study. Latinos represent the largest of minority populations in the United States. According to the 2004 US Census, 35.6 million people, or 12.5% of the nation's residents,...

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Racial diversity
Jan 16, 2012
The Latino Eye Study identified older age and higher pulse pressure as risk factors for 4-year incidence of age-related macular degeneration (AMD) in adult Latinos. Latinos constitute the largest and fastest-growing minority segment of the US population. If recent trends continue, the US Latino population is estimated to increase to 102.6...

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Red meat
Apr 22, 2011
A genetic variation of the transferrin gene is associated with increased risk of AMD in smokers. Oxidative stress is a major environmental risk factor of age-related macular degeneration (AMD) AMD is associated with the increased level of reactive oxygen species (ROS), which may be produced in reactions catalyzed by iron present in the retina....

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Dry Macular Degeneration
Feb 27, 2011
A deficiency of an enzyme that degrades RNA, known as DICER1, may cause dry age-related macular degeneration, according to a new study. Age-related macular degeneration (AMD), which is as prevalent as cancer in industrialized countries, is a leading cause of blindness. In contrast to neovascular AMD, the more common atrophic form of AMD is...

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Japan
Jan 21, 2011
The genomic contribution of the ARMS2/HTRA1 region of chromosome 10q26 among Japanese patients with typical neovascular age-related macular degeneration (nAMD) (also known as typical exudative AMD) and to polypoidal choroidal vasculopathy (PCV) were very similar, according to a recent study. Polypoidal choroidal vasculopathy (PCV) is a...

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cardiovascular system
Oct 21, 2010
The high-density lipoprotein (HDL)-raising allele of the LIPC gene (T) was associated with a reduced risk of age-related macular degeneration (AMD), according to a new study. Higher total cholesterol and LDL levels were associated with increased risk, whereas higher HDL levels tended to reduce the risk of AMD. Hepatic lipase (LIPC), a gene...

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Double helix DNA
Oct 21, 2010
A new study finds the combination of elevated C-reactive protein (CRP) levels and the high-risk genotype of the complement factor H (CFH) gene resulted in a super-additive risk for age-related macular degeneration (AMD) progression. The complement factor H (CFH) gene, involved in the alternate complement pathway, has been consistently...

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DNA double-helix molecule
Oct 16, 2010
With increasing evidence of importance of genetic factors and gene-environment interactions in the etiology of common eye-related disorders, identification of genetic variation associated with a disease risk may help provide insight into the mechanism of disease pathogenesis and reveal novel targets for preventive and therapeutic interventions....

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Tags: AMD, genetics

Polypoidal choroidal vasculopathy
Aug 29, 2010
The polypoidal choroidal vasculopathy (PCV) phenotype in Caucasian patients is associated with the major alleles in three age-related macular degeneration (AMD)-associated loci, suggesting that PCV and AMD are genetically similar, according to a new research study. Polypoidal choroidal vasculopathy (PCV) is characterized by aneurysmal dilations...

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