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Displaying news items tagged with clinical trial (More tags »)
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Laser eye surgery
Mar 28, 2010
The combination of reduced-fluence verteporfin photodynamic therapy (PDT) and variable dosing Lucentis (ranibizumab) is safe and effective for patients with neovascular age-related macular degeneration (AMD) over a 24-month period, according to a new study. Photodynamic therapy is performed by intravenous administration of a drug know as...

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Intravitreal injection
Mar 26, 2010
Intravitreal Avastin (bevacizumab, IVB) was as effective as intravitreal steroid (triamcinolone acetonide, IVT) at improving vision in patients with refractory uveitic cystoid macular edema (CME). Cystoid macular edema (CME) is the most common cause of significant vision loss in patients with uveitis. Medical treatment of CME includes...

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Japan
Feb 17, 2010
Lucentis (ranibizumab) is safe and effective for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) in Japanese patients, according to the EXTEND-I clinical trial. Lucentis was approved for the treatment of wet AMD in Japan in January 2009. The application for approval in Japan was supported by the...

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CATT trial logo
Jan 26, 2010
The first major clinical trial to compare bevacizumab and ranibizumab in a head-to-head fashion has completed enrollment, and the first data analysis is expected in about 1 year. Although the head-to-head comparison of Avastin (bevacizumab, Genentech) and Lucentis (ranibizumab, Genentech) in CATT (Comparisons of age-related macular degeneration...

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Age-related macular degeneration
Jan 26, 2010
A novel platelet-derived growth factor currently being studied in clinical trials may boost the effect of anti-VEGF therapy and provide a benefit in patients with choroidal neovascularization secondary to age-related macular degeneration, according to a speaker at the at Retina 2010 meeting. A phase 1 trial of E10030 (Ophthotech), a PDGF-B...

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Radiation warning symbol
Jan 26, 2010
Interim analysis of a pilot study of combination anti-VEGF therapy and externally delivered radiation for the treatment of age-related macular degeneration has shown encouraging visual acuity and anatomical outcomes and no safety signals, according to a speaker at the Retina 2010 meeting. The IRay system (Oraya Therapeutics) delivers radiation...

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Branch retinal vein occlusion
Jan 26, 2010
Two large-scale randomized clinical trials demonstrate that anti-VEGF therapy significantly improves vision in patients with central or branch retinal vein occlusion, according to a speaker at the Retina 2010 meeting. In the CRUISE study, 130 patients who received a 0.5-mg dose of Lucentis (ranibizumab) in six monthly doses had a mean gain of 14...

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Intravitreal injection
Jan 25, 2010
A flexible, individualized visual acuity-guided regimen after the three initial injections may sustain vision improvement with Lucentis (ranibizumab) and could improve cost-effectiveness and convenience and reduce drug administration–associated risks, according to a new study. In two phase 3 clinical trials, the time course of mean visual...

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Radiation warning symbol
Jan 23, 2010
Oraya Therapeutics announced that enrollment is now underway for a masked and sham-controlled study to demonstrate the efficacy and safety of radiation therapy for the treatment of wet age-related macular degeneration (AMD). The clinical trial is being conducted at seven European sites, and will include a minimum of 150 patients, with...

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Dry macular degeneration
Jan 22, 2010
Acucela announced the launch of its ENVISION Clarity Trial, a Phase 2 clinical trial of ACU-4429, an investigational oral treatment for dry age-related macular degeneration (AMD). ACU-4429 utilizes Acucela's proprietary visual cycle modulation (VCM) technology, and is designed to prevent or inhibit the generation of toxic by-products of the...

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