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DNA double-helix molecule
Aug 28, 2010
A genome-wide association study has identified a possible role of the hepatic lipase gene (LIPC) in advanced AMD, according to a new research report. These findings implicate a new biologic pathway in AMD and provide new avenues for prevention and treatment of AMD. The role of the alternative complement pathway in disease pathogenesis was...

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Obesity
Aug 28, 2010
High-sensitivity C-reactive protein (CRP) and polymorphisms in the CFH and ARMS2/HTRA1 genes are independently associated with risk of AMD, according to a new research study. Higher CRP level tends to confer a higher risk of age-related macular degeneration (AMD) within most genotype groups. Studies have documented the importance of genetic,...

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Mitochondria
Jul 24, 2010
Persons with age-related macular degeneration (AMD) have high levels of mitochondrial (mt)DNA mutations in their retinas compared to age-matched normal retinas, according to a new study. Mitochondria are the structures located within cells that are responsible for energy production. Mitochondria are, in effect, the powerhouses of the cell. All...

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Double helix DNA
May 9, 2010
Higher serum vitamin D level correlated with a slightly decreased incidence of age-related macular degeneration in a study presented at the Association for Research in Vision and Ophthalmology 2010 meeting. The study was the first to report an apparent association between the vitamin D pathway gene CYP24A1 and neovascular AMD, Alexandra C....

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Diabetes
May 8, 2010
iCo Therapeutics announced that the company's Phase I clinical trial study employing iCo-007 in Diffuse Diabetic Macular Edema will be highlighted in a presentation at the Retinal Physician Symposium 2010. Designed and discovered by ISIS Pharmaceuticals Inc, iCo-007 is a second-generation antisense drug targeting c-Raf kinase for the...

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DNA double-helix molecule
Apr 19, 2010
Five genetic varients previously not associated with age-related macular degeneration (AMD) have been identified by a new genome-wide association study. Multiple genetic linkage studies provided strong evidence of susceptibility loci for AMD, notably on chromosomes 1q31 and 10q36. Disease-associated variants near CFH (1q31) and in a cluster of...

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Double helix DNA
Mar 28, 2010
A convergence of scientific and clinical observations and new technologies paved the way for a hallmark genetic discovery that changed the course of AMD research. Four articles published early in 2005 demonstrated an association between AMD and common variants (or polymorphisms) in the complement factor H gene (CFH) on human chromosome 1q31, a...

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Senior women
Mar 27, 2010
Female hormone replacement therapy (HRT) decreases the risk of neovascular age-related macular degeneration (AMD), especially in women who are positive for the ARMS2 genetic polymorphism. It has been reported that hormone replacement therapy decreases the risk of late-stage AMD. It is not clear how female hormones mediate this effect, but...

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DNA double-helix molecule
Feb 23, 2010
A mathematical model has been developed to predict the absolute risk of geographic atrophy and neovascular age-related macular degeneration (AMD) risk based on smoking history and genetic risk factors in individuals of European ancestry. Although AMD was long thought to have primarily an environmental etiology, genetic variation is now known...

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DNA double-helix molecule
Jan 21, 2010
The complement factor H genetic polymorphism rs1061170 is mostly involved in the onset of early age-related macular degeneration (AMD), while the age-related maculopathy susceptibility 2 (ARMS2) genetic varient rs10490924 is associated with the progression of early AMD to more advanced stages, according to a new study. The specific role of...

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