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Displaying news items tagged with adverse drug effects (More tags »)
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Avastin
Jun 16, 2010
The decreased levels of blood VEGF after an intravitreal injection of Avastin (bevacizumab) indicate that Avastin enters the general circulation and may also affect the PEDF levels. There continues to be a concern regarding the long term health consequences of intravitreal Avastin therapy. VEGF plays an important role in many parts of the body...

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Lucentis
May 7, 2010
Intravitreal injection of Lucentis (ranibizumab) does not produce a therapeutic effect in the fellow eye of patients with bilateral exudative age-related macular degeneration (AMD), according to a new study. In patients with exudative AMD, intravitreal anti-vascular endothelial growth factor (VEGF) therapy can lead to stabilization and even...

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Avastin
Apr 21, 2010
Intravitreal Avastin (bevacizumab) for age-related macular degeneration (AMD) has been associated with the onset of tonic–clonic (grand mal) epileptic seziures, according to a recent case report. An 81-year-old female was brought to the emergency department by emergency medical services (EMS) after 3 witnessed seizures. Thirty minutes earlier...

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Avastin
Mar 30, 2010
A series of 5 cases of severe intraocular inflammation that developed after an intravitreal injection of Avastin (bevacizumab) is reported. Avastin (bevacizumab) is approved for intravenous administration for the treatment of metastatic colon cancer. In ophthalmology, Avastin has been used widely as an off-label treatment for ocular disorders...

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Laboratory glassware
Feb 20, 2010
Avastin impairs phagocytic activity of retinal pigment epithelial (RPE) cells cultured in a laboratory, according to a new study. The retinal pigment epithelium (RPE) is a layer of "nurse cells" located immediately adjacent to the photoreceptors that provide the photoreceptors with nourishment and removes their waste products. The...

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cardiovascular system
Feb 17, 2010
Avastin (bevacizumab) was not detectable in untreated fellow eyes after contralateral intravitreal injection of Avastin, according to a new study. Concerns have been raised regarding the systemic safety of long term intravitreal anti-VEGF therapy. In a small, nonrandomized clinical study, intravenous Avastin for the treatment of neovascular AMD...

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Avastin
Jan 26, 2010
Avastin (bevacizumab) stored for long periods of time showed evidence of increased large particulate matter, possibly resulting in increased IOP, a presenter said at the Hawaiian Eye 2010 meeting. "Avastin is not formulated for sitting in a plastic syringe for an extended period of time. It is also not formulated for sitting in a plastic...

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Central retinal vein occlusion
Dec 23, 2009
A series of patients that suffered retinal vascular occlusion following Avastin (bevacizumab) injection are reported. It is known that anti-VEGF agents cause vasoconstriction, a narrowing of retinal blood vessels, and this could, at least in theory, increase the risk of blood vessel closure (occlusion). It has been reported that Lucentis...

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Visudyne
Nov 26, 2009
Photodynamic therapy (PDT) results in transient functional deterioration in the retina, according to a new study. Photodynamic therapy with verteporfin temporarily closes choroidal neovascular complexes via the release of oxygen free radicals. This process also liberates angiogenic and inflammatory agents that may increase vascular permeability...

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Intraocular pressure
Nov 20, 2009
Although temporary increases in intraocular pressure (IOP) are a known adverse effect of anti-VEGF medications for age-related macular degeneration (AMD), some patients develop persistent IOP — even without predisposing risk factors, according to research presented at the American Academy of Ophthalmology Annual Meeting. Whether this adverse...

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