MyVisionTest News Archive

Displaying news items tagged with clinical trial (More tags »)
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Age-related macular degeneration
Dec 24, 2009
Ophthotech has received $30 million in Series B financing to support a phase 2 combination trial of E10030, the company's lead product candidate for treating age-related macular degeneration, the company announced. In a phase 1 combination study, E10030, an anti-platelet-derived growth factor (PDGF) aptamer, demonstrated effectiveness when...

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Senior women
Dec 17, 2009
Low-dose aspirin has no effect on the risk of age-related macular degeneration (AMD) in adult women over 10 years of treatment and follow-up, according to a new research study. There are several possible pathways through which aspirin may exert a beneficial effect in AMD. At low doses (100 mg every other day), aspirin irreversibly inhibits...

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VEGF-Trap
Nov 24, 2009
The CLEAR-IT 2 trial was a phase 2 study of the safety and efficacy of VEGF Trap-Eye in patients with neovascular age-related macular degeneration (AMD). An extension of the CLEAR-IT 2 trial followed patients from the original trial. Below are the results of the initial CLEAR-IT 2 as well as 6-month data from the extension stage. CLEAR-IT 2...

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Laboratory glassware
Nov 22, 2009
Advanced Cell Technology (ACT), Inc. announced that it filed an Investigational New Drug (IND) Application with the US Food and Drug Administration (FDA) to initiate a Phase I/II multicenter study using embryonic stem cell derived retinal cells to treat patients with Stargardt's Macular Dystrophy (SMD). While there is currently no treatment...

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Central retinal vein occlusion
Oct 26, 2009
Genentech, Inc. announced results from two Phase III studies of Lucentis (ranibizumab) in macular edema due to retinal vein occlusion (RVO), which showed patients given Lucentis had significant improvement in best-corrected visual acuity (BCVA) at six months compared to patients receiving sham injections. Results from both trials were presented at...

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Diabetes
Oct 22, 2009
limera Sciences has reported 18-month safety and efficacy results of its Iluvien implant for treating patients with diabetic macular edema. The 36-month, open-label, phase 2 study - which is being conducted concurrently with the pivotal phase 3 FAME (Fluocinolone acetonide in diabetic macular edema) trial - is evaluating the systemic exposure...

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Radiation warning symbol
Oct 22, 2009
The use of epimacular brachytherapy (radiation) combined with Avaastin (bevacizumab) appears safe for treatment of neovascular age-related macular degeneration and reduces the dosing burden of anti-VEGF therapy. After 2 years of follow-up in 34 patients treated with strontium 90 and Avastin in a phase 2 study, 80% of patients who had cataract...

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Central retinal vein occlusion
Oct 22, 2009
Inhibition of VEGF in macular edema secondary to central retinal vein occlusion provides rapid and sustained visual acuity improvements through 6 months, according to a speaker at Retina Congress 2009. The data are from the phase 3 CRUISE trial on Lucentis (ranibizumab) vs. sham and will be presented to the U.S. Food and Drug Administration...

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Central retinal vein occlusion
Sep 25, 2009
Scientists have identified the first long-term, effective treatment to improve vision and reduce vision loss associated with blockage of large veins in the eye. The Standard Care vs. Corticosteroid for Retinal Vein Occlusion (SCORE) study, conducted at 84 clinical sites, found that eye injections of a corticosteroid medication could reduce...

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Lucentis
Sep 25, 2009
Lucentis (ranibizumab) had a beneficial effect on visual outcome, along with safe and well-tolerated results, in treating neovascular age-related macular degeneration (AMD), according to the SAILOR study. The SAILOR study was a phase IIIb follow-up study to the MARINA and ANCHOR studies to evaluate the long-term safety and efficacy of Lucentis...

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