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DNA double-helix molecule
Dec 21, 2009
Genes that control toll-like receptors (TLRs), molecules located on the surface of cells that with play an important role in immunity, are not associated with risk for age-related macular degeneration (AMD), according to a new study. Epidemiologic studies suggest that personal risk factors (such as obesity), environmental risk factors (eg...

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Tags: AMD, genetics

Polypoidal choroidal vasculopathy
Nov 26, 2009
The LOC387715 A69S genotype is associated with the degree of exudative activity in patients with polypoidal choroidal vasculopathy (PCV), according to a new study. PCV is a distinct clinical entity that is characterized by polypoidal vasculature with interconnecting choroidal vessels. It has been proposed that PCV may be a variant of...

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DNA double-helix molecule
Oct 24, 2009
Genetic variants, especially located on chromosomes 1 and 10, appear to correlate with phenotypic expressions of age-related macular degeneration. The most well known of these genetic risk factors, Ivana K. Kim, MD, said at Retina Subspecialty Day preceding the American Academy of Ophthalmology meeting, is complement factor H (CFH), which has...

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Double helix DNA
Oct 14, 2009
Persons with the CFH CC genotype have an increased likelihood of bilateral compared with unilateral age-related macular degeneration (AMD), according to a new study. AMD is an irreversible debilitating disease with complex genetic and environmental contributors. Recent research has focused on identifying the genetic predisposition to AMD, and...

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Diagram of a mitochondria
Jun 26, 2009
A new study finds that the mitochondrial (mt)DNA in the retinas of patients with age-related macular degeneration (AMD) contained more single-nucleotide polymorphisms (SNPs) within the control region of the geneome compared to normal retinas. There was an increased frequency of mtDNA SNPs associated with haplogroups J, T and U in patients with...

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DNA double-helix molecule
May 22, 2009
Analysis of data from the DAWN genetics substudy of Lucentis (ranibizumab) trials found that the fifth component of complement (C5) I802V polymorphism was associated with a risk of age-related macular degeneration, with a noted reaction to the anti-VEGF drug. "The C5 I802V polymorphism was associated with differential response to ranibizumab,...

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Lucentis
Apr 24, 2009
Exudative AMD patients with the compliment factor H (CFH Y402H) high risk genotype (CC) received approximately one more Lucentis injection over a 9 month follow-up period than persons who do not have the high risk genotype. Genetic studies have made advancements in establishing the molecular cause of AMD. Two genes that seem to greatly...

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Macular degeneration
Apr 23, 2009
AREDS investigators have constructed a statistical model using known genetic, demographic and environmental risk factors that is able to accurately predict the progression to advanced AMD with 81.3% certainty. Knowledge about genetic and epidemiologic risk factors for age-related macular degeneration (AMD) has grown exponentially in recent...

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Double helix DNA
Mar 14, 2009
Genetic research offers great potential to the eye, and we are very close to getting clinical applications from ocular genetics. We already know a great deal about monogenic disorders in which there is a one-to-one correlation. For example, we know that the ABCA4 mutation will lead to Stargardt’s disease. In complex disease, we know a...

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Tags: AMD, genetics

Double helix DNA
Feb 16, 2009
A study finds that persons homozygous for the compliment factor H high-risk allele have a smaller treatment response to the AREDS vitamin/mineral supplement than persons homozygous for the low-risk allele. A retrospective analysis was undertaken of 876 white participants in the Age-Related Eye Disease Study (AREDS) study with categories 3 and 4...

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