MyVisionTest News Archive

Displaying news items tagged with CNV (More tags »)
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Laboratory mouse
Apr 19, 2009
A new study on mice finds that locally or orally-administered pazopanib, a multitargeted kinase inhibitor, strongly suppresses choroidal neovascularization (CNV). The major effect of anti-VEGF drugs such as Lucentis and Avastin is to reduce the vascular permeability of CNV, which results in rapid reduction in subretinal and intraretinal fluid...

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Monkey
Apr 17, 2009
ESBATech has announced preclinical results, which demonstrate efficacy of topical ESBA105, an anti-Tumor Necrosis Factor (TNF) single-chain antibody fragment, in a model for choroidal neovascularization (CNV). In wet age-related macular degeneration (wet AMD), CNV causes the formation of new blood vessels growing behind the retina, which can...

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Macular degeneration
Mar 14, 2009
A research study finds that RPE cells extracted from surgically excised CNV-membranes employ both VEGF and fibroblast growth factor to activate endothelial cells Choroidal neovascularisation (CNV) as a feature of exudative age-related macular degeneration (AMD) is partially regulated by retinal pigment epithelium (RPE). In this study, the...

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Tags: wet AMD, CNV, VEGF

Ocular histoplasmosis
Jan 13, 2009
The anti-VEGF drugs Lucentis and Avastin are effective in the treatment of choroidal neovascularization (CNV) secondary to multifocal choroiditis, according to a new research report. Multifocal choroiditis (MFC) is an inflammatory condition, occasionally associated with choroidal neovascularization (CNV). Some cases of MFC are believed to be...

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Laboratory mouse
Dec 5, 2008
A new study finds that an integrin αvβ3 antagonist known as BS-1417 inhibits choroidal neovascularization (CNV) in mice. Integrins are a class of cell surface receptors that play a key role in the regulation of numerous key processes, including cell proliferation, migration, and differentiation. Integrins bind with various components in the...

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Diabetes
Nov 22, 2008
This article investigates the role of integrins in proliferative diabetic retinopathy, and concludes that they represent a potential target for the development of new drug therapies for the disease. Integrins have also been identified as playing a role in the pathogenesis of choroidal neovascularization. Proliferative diabetic retinopathy...

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Laboratory mouse
Nov 19, 2008
A new study reports that the somatostatin analogue RFE-011 effectively inhibited retinal and choroidal neovascularization in mice, and was able to penetrate the eye after topical administration. The presence of somatostatin receptors on tumour cells and on proliferating vascular endothelium has led researchers to investigate the antiangiogenic...

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fluorescein angiography
Nov 16, 2008
A new study reports good success imaging classic choroidal neovascularization (CNV) in patients with wet age-related macular degeneration (AMD) using infared photography. Wet AMD is traditionally diagnosed using fluorescein angiography (FA). Despite advances in noninvasive imaging technology, such as optical coherence tomography (OCT), most...

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Night vision
Nov 14, 2008
A new study linking poor vision under dim light conditions to progression of AMD has been published by the Complications of Age-related Macular Degeneration Prevention Trial (CAPT) study group. This study supports similar research findings published several months ago that night vision symptoms are an independent risk factor for progression of...

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Tags: CNV, AMD

Angioid streaks
Oct 14, 2008
A new study finds that Avastin is effective in treating choroidal neovascularization (CNV) arising from angioid streaks. Intravitreal Avastin (bevacizumab), initially used for the off-label treatment of neovascular age-related macular degeneration (AMD), is increasingly being used to treat various other conditions associated with CNV. Angioid...

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