MyVisionTest News Archive

Displaying news items tagged with wet AMD (More tags »)
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Polypoidal choroidal vasculopathy
Aug 29, 2010
The polypoidal choroidal vasculopathy (PCV) phenotype in Caucasian patients is associated with the major alleles in three age-related macular degeneration (AMD)-associated loci, suggesting that PCV and AMD are genetically similar, according to a new research study. Polypoidal choroidal vasculopathy (PCV) is characterized by aneurysmal dilations...

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Macular degeneration
Aug 26, 2010
Despite the success of intravitreal anti-VEGF therapy in treating age-related macular degeneration, serious concerns abound over the potential burden of repeated injections. Although still in the early stages of development, candidate drug therapies could offer the theoretical potential of enhancing anti-VEGF efficacy and, perhaps, leading to...

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DNA double-helix molecule
Jul 29, 2010
A new study finds that a single intravitreal dose of Sirna-027, a small interfering RNA targeting vascular endothelial growth factor receptor-1, up to 1600 µg/eye was well tolerated and that stabilization or improvement in visual acuity and foveal thickness occured in patients with choroidal neovascularization (CNV) resulting from neovascular...

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cardiovascular system
Jul 25, 2010
Cardiovascular risk factors such as smoking, hypertension, and atherosclerosis seem to play an important role in the development of choroidal neovascularization (CNV). Several cross-sectional studies have provided evidence suggesting that choroidal and retinal blood flow is decreased in AMD. The presence of abnormal choroidal circulation...

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Lucentis
Jul 24, 2010
The addition of standard-fluence verteporfin photodynamic therapy (PDT) delivered on the first day to a Lucentis (ranibizumab) regimen for choroidal neovascularisation (CNV) secondary to age-related macular degeneration (AMD) does not improve outcomes at 1 year of follow-up compared with Lucentis monotherapy, according to a new study. Despite...

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Macular drusen
Jun 27, 2010
The most common – and under-diagnosed – genetic disease in humans may be a cause of macular degeneration, Medical College of Georgia researchers report. They are pursuing a link between hemochromatosis, which results in iron overload, and the wet form of macular degeneration. They suspect that too much iron hastens normal aging of the eyes....

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Tags: wet AMD, iron

Intravitreal injection
Jun 27, 2010
Monthly Lucentis injections do not reduce the rate of CNV development in untreated fellow eyes, according to a new study. Several epidemiologic studies have suggested that patients with unilateral neovascular age-related macular degeneration (AMD) have a substantial risk of developing choroidal neovascularization (CNV) in their fellow eye. The...

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Macular degeneration
Jun 27, 2010
Combination therapies generated greater visual acuity gains with fewer reinjections compared with monotherapy in a phase 2 study of patients with exudative age-related macular degeneration. In the phase 2 RADICAL (Reduced fluence Visudyne anti-VEGF-dexamethasone in combination for AMD lesions) study, mean gain in visual acuity from baseline in 3...

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Laboratory mouse
Jun 27, 2010
A new study finds that inhibition of CXCR4 may be useful in preventing neovascularization but does not appear to have an effect on already established angiogenesis, whereas a multiple receptor tyrosine kinase inhibitor (SU14813) reduced the size of previously formed lesions. Endothelial precursor cells (EPCs) derived from hematopoietic stem...

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Pigment epithelial detachment
Jun 17, 2010
In patients with age-related macular degeneration (AMD) and pigment epithelial detachment (PED) secondary to occult choroidal neovascularization (CNV), Avastin (bevacizumab) therapy decreased PED height but this does not necessarily correlate with improvment in visual acuity (VA), according to a new study. A PED occurs when fluid enters the...

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