MyVisionTest News Archive

Displaying news items tagged with Avastin (More tags »)
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CATT trial logo
Jan 26, 2010
The first major clinical trial to compare bevacizumab and ranibizumab in a head-to-head fashion has completed enrollment, and the first data analysis is expected in about 1 year. Although the head-to-head comparison of Avastin (bevacizumab, Genentech) and Lucentis (ranibizumab, Genentech) in CATT (Comparisons of age-related macular degeneration...

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Avastin
Jan 26, 2010
Avastin (bevacizumab) stored for long periods of time showed evidence of increased large particulate matter, possibly resulting in increased IOP, a presenter said at the Hawaiian Eye 2010 meeting. "Avastin is not formulated for sitting in a plastic syringe for an extended period of time. It is also not formulated for sitting in a plastic...

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Macular degeneration
Jan 24, 2010
Retinal vessel responses to flickering light are altered in patients with age-related macular degeneration (AMD) and are not improved after successful Avastin (bevacizumab) therapy. The retina has the ability to regulate blood flow in response to different metabolic demands. Several animal and human studies demonstrated an increase in retinal...

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Tags: Avastin, AMD

Avastin
Jan 20, 2010
Avastin (bevacizumab) decreases survival of cultured retinal pigment epithelial cells stressed by hydrogen peroxide, according to a new study. Vascular endothelial cell growth factor (VEGF) is strongly induced by oxidative stress in retinal pigment epithelial (RPE) cells, and VEGF-A is a survival factor for various cell types. VEGF-A expression...

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Central retinal vein occlusion
Dec 23, 2009
A series of patients that suffered retinal vascular occlusion following Avastin (bevacizumab) injection are reported. It is known that anti-VEGF agents cause vasoconstriction, a narrowing of retinal blood vessels, and this could, at least in theory, increase the risk of blood vessel closure (occlusion). It has been reported that Lucentis...

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Eye surgery
Dec 22, 2009
A new study finds that pars plana vitrectomy (ppV) with subretinal coapplication of recombinant tissue plasminogen activator (TPA) and Avastin (bevacizumab), and fluid–gas exchange improved visual acuity in most patients with neovascular age-related macular degeneration (AMD) with submacular haemorrhage (SMH). Eyes with large subretinal...

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Intravitreal injection
Dec 21, 2009
The MARINA and ANCHOR clinical trials of Lucentis (ranibizumab) therapy for exudative age-related macular degeneration (AMD) followed a fixed dosage regimen and fixed duration of 2 years. Hence, the trials did not provide any information about the “when to stop” endpoint. Because anti-VEGF drugs are angiostatic - they inactivate rather than...

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Myopic macular degeneration
Dec 14, 2009
The 2 year visual outcome of intravitreal Avastin (bevacizumab [IVB]) is superior to that of photodynamic therapy (PDT) for myopic choroidal neovascularizations (mCNVs), according to a new research report. Extreme myopia may result in degenerative changes of the retina. These degenerative changes may lead to complications such as retinal...

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Laser eye surgery
Dec 14, 2009
Intravitreal Avastin (bevacizumab) and low fluence photodynamic therapy (PDT) have a synergistic effect when applied together in the treatment of neonascular age-related macular degeneration (AMD), according to a new research report. PDT is performed by intravenous administration of a drug know as verteporfin, then activating the drug within...

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Retinal angiomatous proliferation
Nov 26, 2009
Treat and Extend is an effective dosing strategy for the treatment of patients with retinal angiomatous proliferation, according to a new study. Since the first suggestion of a non-monthly dosing regimen in the PrONTO study, many retinal specialists have moved toward dosing individualization, with maintenance therapy provided on an as-needed...

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