This calculator sums up individual risk factors for AMD and generates an overall probability score for the development of advanced AMD over the next 6 years. It is based upon data for Caucasian participants in the Age-Related Eye Disease Study (AREDS), a longitudinal study of AMD that ended in December 2005. The original research that made this calculator possible is discussed here. The free full text of the original research article is available here.
Definitions: The above research paper gives the following definition of progression: "Progressors were those individuals with early or intermediate AMD at baseline who progressed to advanced AMD during follow-up, and individuals with advanced AMD in one eye at baseline who progressed to advanced AMD in both eyes." Advanced AMD is defined as either neovascular AMD or central geographic atrophy.
Genotype Questions: The precision of the estimation of your individual risk for developing advanced AMD improves substantially if you know your genotype. There are many retail DNA testing services currently available that can provide you with this information. However, I am not aware of any single test that currently types all six genes used in this calculator (but this will probably change with time).
Why does knowing you risk for advanced AMD matter? High-risk individuals should monitor their vision more frequently. Self-monitoring is the best way to detect disease progression in a timely manner. High-risk individuals should also be encouraged to follow a healthy lifestyle by not smoking, eating vegetables and fish, maintaining a normal weight and getting exercise, and taking antioxidant–mineral supplements.
Disclaimer: Please note that my only contribution to this risk calculator is to implement the research that has been published by others and to make it freely available to the public. I take no credit (or blame) for the accuracy or utility of this calculator.
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