AMD Risk Calculator

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This calculator combines individual risk factors for AMD and generates an overall probability score for advanced AMD. It is based upon published data regarding risk factors for AMD in individuals of European ancestry. The original research that made this calculator possible is discussed here. The original research article is available here.

Genotype Questions: The estimation of your individual risk for developing advanced AMD using this calculator requires that you know your genotype. There are many retail DNA testing services currently available that can provide you with this information. However, I am not aware of any single test that currently provides all of the information required for this calculator (but that will probably change with time).

Why does knowing you risk for advanced AMD matter? High-risk individuals should monitor their vision more frequently. Self-monitoring is the best way to detect disease progression in a timely manner. High-risk individuals should also be encouraged to follow a healthy lifestyle by not smoking, eating vegetables and fish, maintaining a normal weight and getting exercise, and taking antioxidant-mineral supplements. Folic acid and B-vitamin supplements also have demonstrated value in preventing AMD.

Variable     Description
Current Age
50-4 Current age is between 50 and 54 years
55-9 Current age is between 55 and 59 years
60-4 Current age is between 60 and 54 years
65-9 Current age is between 65 and 69 years
70-4 Current age is between 70 and 74 years
75-9 Current age is between 75 and 79 years
80+ Current age is 80 years or greater
Smoking Status
Current smoking Currently smokes any tobacco product
Past smoking Does not currently smoke, but has smoked for at least 6 months in the past
Never smoked Has never smoked
Genetics
rs1048663
GG
Homozygous GG at the rs1048663 locus
rs1048663
GA
Heterozygous GA at the rs1048663 locus
rs1048663
AA
Homozygous AA at the rs1048663 locus
rs2274700
CC
Homozygous CC at the rs2274700 locus
rs2274700
CT
Heterozygous CT at the rs2274700 locus
rs2274700
TT
Homozygous TT at the rs2274700 locus
rs412852
CC
Homozygous CC at the rs412852 locus
rs412852
CT
Heterozygous CT at the rs412852 locus
rs412852
TT
Homozygous TT at the rs412852 locus
rs11582939
CC
Homozygous CC at the rs11582939 locus
rs11582939
CT
Heterozygous CT at the rs11582939 locus
rs11582939
TT
Homozygous TT at the rs11582939 locus
rs1280514
GG
Homozygous GG at the rs1280514 locus
rs1280514
GA
Heterozygous GA at the rs1280514 locus
rs1280514
AA
Homozygous AA at the rs1280514 locus
rs10490924
ARMS2 GG
Homozygous GG for the LOC387715 A69S polymorphism (rs10490924), also known as ARMS2, in the LOC387715/HTRA1 region of chromosome 10.
rs10490924
ARMS2 GT
Heterozygous for the LOC387715 A69S polymorphism (rs10490924). This is a nonsynonymous coding single nucleotide polymorphism in exon 1 of LOC387715, resulting in a substitution of the amino acid serine for alanine at codon 69
rs10490924
ARMS2 TT
Homozygous TT for the LOC387715 A69S polymorphism (rs10490924)
rs2230199
C3 CC
Homozygous CC for complement factor 3 (C3) R102G (rs2230199)
rs2230199
C3 CG
Heterozygous for complement factor 3 (C3) R102G (rs2230199), the nonsynonymous coding single nucleotide polymorphism in exon 3 of C3 resulting in the amino acid change of glycine to arginine at codon 102
rs2230199
C3 GG
Homozygous GG for complement factor 3 (C3) R102G (rs2230199)
MTND2*LHON4917G
mitochondrial DNA 4917, A allele
A4917G, a non-synonymous mitochondrial DNA polymorphism associated with mitochondrial haplogroup T.
MTND2*LHON4917G
mitochondrial DNA 4917, G allele
A4917G mitochondrial DNA polymorphism

Disclaimer: Please note that my only contribution to this risk calculator is to implement the research that has been published by others and to make it freely available to the public. I take no credit (or blame) for the accuracy or utility of this calculator.

Privacy Notice: We respect your privacy and do not collect or retain any information from this form.