AMD Risk Calculator

This calculator combines individual risk factors for AMD and generates an overall probability score for advanced AMD. It is based upon published data regarding risk factors for AMD in individuals of European ancestry. The original research that made this calculator possible is discussed here. The original research article is available here.

Genotype Questions: The estimation of your individual risk for developing advanced AMD using this calculator requires that you know your genotype. There are many retail DNA testing services currently available that can provide you with this information. However, I am not aware of any single test that currently provides all of the information required for this calculator (but that will probably change with time).

Why does knowing you risk for advanced AMD matter? High-risk individuals should monitor their vision more frequently. Self-monitoring is the best way to detect disease progression in a timely manner. High-risk individuals should also be encouraged to follow a healthy lifestyle by not smoking, eating vegetables and fish, maintaining a normal weight and getting exercise, and taking antioxidant-mineral supplements. Folic acid and B-vitamin supplements also have demonstrated value in preventing AMD.

Variable			Description
Current Age
50-4	Yes	No	Current age is between 50 and 54 years
55-9	Yes	No	Current age is between 55 and 59 years
60-4	Yes	No	Current age is between 60 and 54 years
65-9	Yes	No	Current age is between 65 and 69 years
70-4	Yes	No	Current age is between 70 and 74 years
75-9	Yes	No	Current age is between 75 and 79 years
80+	Yes	No	Current age is 80 years or greater
Smoking Status
Current smoking	Yes	No	Currently smokes any tobacco product
Past smoking	Yes	No	Does not currently smoke, but has smoked for at least 6 months in the past
Never smoked	Yes	No	Has never smoked
Genetics
rs1048663 GG	Yes	No	Homozygous GG at the rs1048663 locus
rs1048663 GA	Yes	No	Heterozygous GA at the rs1048663 locus
rs1048663 AA	Yes	No	Homozygous AA at the rs1048663 locus
rs2274700 CC	Yes	No	Homozygous CC at the rs2274700 locus
rs2274700 CT	Yes	No	Heterozygous CT at the rs2274700 locus
rs2274700 TT	Yes	No	Homozygous TT at the rs2274700 locus
rs412852 CC	Yes	No	Homozygous CC at the rs412852 locus
rs412852 CT	Yes	No	Heterozygous CT at the rs412852 locus
rs412852 TT	Yes	No	Homozygous TT at the rs412852 locus
rs11582939 CC	Yes	No	Homozygous CC at the rs11582939 locus
rs11582939 CT	Yes	No	Heterozygous CT at the rs11582939 locus
rs11582939 TT	Yes	No	Homozygous TT at the rs11582939 locus
rs1280514 GG	Yes	No	Homozygous GG at the rs1280514 locus
rs1280514 GA	Yes	No	Heterozygous GA at the rs1280514 locus
rs1280514 AA	Yes	No	Homozygous AA at the rs1280514 locus
rs10490924 ARMS2 GG	Yes	No	Homozygous GG for the LOC387715 A69S polymorphism (rs10490924), also known as ARMS2, in the LOC387715/HTRA1 region of chromosome 10.
rs10490924 ARMS2 GT	Yes	No	Heterozygous for the LOC387715 A69S polymorphism (rs10490924). This is a nonsynonymous coding single nucleotide polymorphism in exon 1 of LOC387715, resulting in a substitution of the amino acid serine for alanine at codon 69
rs10490924 ARMS2 TT	Yes	No	Homozygous TT for the LOC387715 A69S polymorphism (rs10490924)
rs2230199 C3 CC	Yes	No	Homozygous CC for complement factor 3 (C3) R102G (rs2230199)
rs2230199 C3 CG	Yes	No	Heterozygous for complement factor 3 (C3) R102G (rs2230199), the nonsynonymous coding single nucleotide polymorphism in exon 3 of C3 resulting in the amino acid change of glycine to arginine at codon 102
rs2230199 C3 GG	Yes	No	Homozygous GG for complement factor 3 (C3) R102G (rs2230199)
MTND2*LHON4917G mitochondrial DNA 4917, A allele	Yes	No	A4917G, a non-synonymous mitochondrial DNA polymorphism associated with mitochondrial haplogroup T.
MTND2*LHON4917G mitochondrial DNA 4917, G allele	Yes	No	A4917G mitochondrial DNA polymorphism

Disclaimer: Please note that my only contribution to this risk calculator is to implement the research that has been published by others and to make it freely available to the public. I take no credit (or blame) for the accuracy or utility of this calculator.

Privacy Notice: We respect your privacy and do not collect or retain any information from this form.